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Nadia A. Khan

Assistant Professor
General Internal Medicine

Education

 BSc with Distinction University of Alberta, Microbiology

MD, University of Alberta, Honors in Research

FRCPC, University of Calgary, General Internal Medicine Fellowship
 

Research Summary

My research in hypertension includes several studies evaluating the need for antihypertensive medication drug therapy using the Canadian Heart Health Survey. We determined that although a significant number of patients with hypertension were untreated as per the Canadian guidelines, 25% of hypertensive Canadians were actually low cardiovascular risk, not requiring any medications (Can J Card 2002;18(6): 657-61). In a separate study, we determined that the majority of elderly hypertensive patients that were unaware of their hypertensive status would not require meet criteria for needing drug therapy. (BMC Cardiovasc Disord. 2005;5(1):4).  I contribute towards a national knowledge translation strategy to improve hypertension management in Canada through the Canadian Hypertension Recommendations (first author) (Can J Cardiol. 2005;21(8):657-72, Can J Cardiol. 2004;20(1):41-54). These studies and recommendations papers have been used nationally and internationally to guide health care workers and policy makers in the treatment of hypertension.

 

Recent Publications

•Khan NA, McAlister FA, Campbell NRC, Feldman RD, Mahon J, Lewanczuk R, Rabkin SW, Zarnke KB, Hemmelgarn B, Lebel M, Levine M, Herbert C, for the Canadian Hypertension Education Program. The 2006 Canadian Recommendations for the Management of Hypertension: Therapy. Canadian Journal of Cardiology. 2006 May 15;22(7):583-93.
•Campbell NR, Khan NA, Grover S. Assessment of absolute cardiovascular risk as a starting point for interventions to reduce cardiovascular risk in hypertensive patients. J Hypertens. 2006 Sep;24(9):1683-5.
•Chou SH, Hemmelgarn BR, Wiebe N, Culleton BF, Manns BJ, Klarenbach S, Gill JS, Khan NA, Tonelli M for the Alberta Kidney Disease Network. Differences in use of peritoneal dialysis and survival among East Asian, Indo Asian and White end-stage renal disease patients in Canada. Am J Kidney Dis. 2006 Dec;48(6):964-71.
•Khan N, Ma I*, Thompson CR, Humphries K, Salem D, Sarnak M, Levin A. Kidney function and mortality among patients with left ventricular systolic dysfunction. J Am Soc Nephrol. 2006;17(1):244-53.
•Khan N, McAlister F. Beta blockers for the treatment of primary hypertension. Lancet. 2006 Jan 21;367(9506):208.
•Khan N, Rahim S, Anand S, Panju A. Does the clinical exam predict significant peripheral arterial disease? JAMA. 2006;295(5):536-46.
•Khan NA, Hemmelgarn B, Tonelli M, Thompson C, Levin A. Troponins and Meta analysis. Circulation 2006;113(20) (letter to editor).
•Khan NA, McAlister FA. Beta-blockers for the treatment of hypertension: a re-examination of published data. CMAJ. 2006 Jun 6;174(12):1737-42. (also will be featured in ACP Journal Club).
•Hemmelgarn BR, Chou S, Wiebe N, Culleton BF, Manns BJ, Klarenbach S, Khan NA, Gourishankar S, Yeates KE, Gill JS, Tonelli M. Differences in use of peritoneal dialysis and survival among East Asian, Indo Asian, and white ESRD patients in Canada. Am J Kidney Dis. 2006 Dec;48(6):964-71. Erratum in: Am J Kidney Dis. 2007 Feb;49(2):348.  PMID: 17162151.
•Khan N, McAlister FA. Do beta-blockers have a role in treating hypertension? Yes. Can Fam Physician. 2007 Apr;53(4):614-21. PMID: 17872702.
•Khan N, McAlister FA.Rebuttal: Do beta-blockers have a role in treating hypertension? Yes. Can Fam Physician. 2007 May;53(5):800-3. PMID: 17872734.
•Khan N. Perioperative Management of Diabetes Mellitus. Canadian Journal of General Internal Medicine. 2007.
•Khan NA, Hemmelgarn B, Padwal R, Larochelle P, Mahon JL, Lewanczuk RZ, McAlister FA, Rabkin SW, Hill MD, Feldman RD, Schiffrin EL, Campbell NR, Logan AG, Arnold M, Moe G, Campbell TS, Milot A, Stone JA, Jones C, Leiter LA, Ogilvie RI, Herman RJ, Hamet P, Fodor G, Carruthers G, Culleton B, Burns KD, Ruzicka M, deChamplain J, Pylypchuk G, Gledhill N, Petrella R, Boulanger JM, Trudeau L, Hegele RA, Woo V, McFarlane P, Touyz RM, Tobe SW; Canadian Hypertension Education Program.The 2007 Canadian Hype
•Khan NA, McAlister FA. Beta-blockers for the treatment of hypertension: a re-examination of published data. CMAJ. 2007 Feb (letter to the Editor).
•Ma IW, Khan NA, Kang A, Zalunardo N, Palepu A. Systematic review identified suboptimal reporting and use of race/ethnicity in general medical journals. J Clin Epidemiol. 2007 Jun;60(6):572-8. Epub 2007 Mar 26. PMID: 17493512.
•Ma, I, N. Khan, A Kang, N Zalunardo, A Palepu. Reporting of Race/Ethnicity and Socioeconomic Factors in General Medical Journals. J Clin Epidemiol. 2007 Jun;60(6):572-8. Epub 2007 Mar 26.
•Padwal RS, Hemmelgarn BR, McAlister FA, McKay DW, Grover S, Wilson T, Penner B, Burgess E, Bolli P, Hill M, Mahon J, Myers MG, Abbott C, Schiffrin EL, Honos G, Mann K, Tremblay G, Milot A, Cloutier L, Chockalingam A, Khan NA, Rabkin SW, Dawes M, Touyz RM, Tobe SW; Canadian Hypertension Education Program. The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: part 1- blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol. 2007 May
•Wardman D, Quantz D, Tootoosis J, Khan N. Tobacco cessation drug therapy among Canada's Aboriginal people. Nicotine Tob Res. 2007 May;9(5):607-11.
•Hemmelgarn BR, Chen G, Walker R, McAlister FA, Quan H, Tu K, Khan N, Campbell N. Trends in antihypertensive drug prescriptions and physician visits in Canada between 1996 and 2006. Can J Cardiol. 2008;24(6):507-12.
•Khan NA, Hemmelgarn B, Herman RJ, Rabkin SW, McAlister FA, Bell CM, Touyz RM, Padwal R, Leiter LA, Mahon JL, Hill MD, Larochelle P, Feldman RD, Schiffrin EL, Campbell NR, Arnold MO, Moe G, Campbell TS, Milot A, Stone JA, Jones C, Ogilvie RI, Hamet P, Fodor G, Carruthers G, Burns KD, Ruzicka M, dechamplain J, Pylypchuk G, Petrella R, Boulanger JM, Trudeau L, Hegele RA, Woo V, McFarlane P, Vallée M, Howlett J, Katzmarzyk P, Tobe S, Lewanczuk RZ; Canadian Hypertension Education Program. The 2008 Ca
•Khan NA, Palepu A, Norena M, Ayas N, Wong H, Chittock D, Hameed M, Dodek PM. Differences in Hospital Mortality among Critically Ill Patients of Asian, Native Indian and European Descent. Chest. 2008;134(6):1217-22.
•Padwal RJ, Hemmelgarn BR, Khan NA, Grover S, McAlister FA, McKay DW, Wilson T, Penner B, Burgess E, Bolli P, Hill MD, Mahon J, Myers MG, Abbott C, Schiffrin EL, Honos G, Mann K, Tremblay G, Milot A, Cloutier L, Chockalingam A, Rabkin SW, Dawes MD, Touyz RM, Bell C, Burns KD, Ruzicka M, Campbell NR, Lebel M, Tobe SW; Canadian Hypertension Education Program. The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 1 - blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol. 2008;24(6):455-63.
•Palepu A, Khan NA, Norena M, Chittock D, Wong H, Dodek P. Role of Drug Dependence in Outcome of HIV and Critically Ill Patients. J Crit Care. 2008;23(3):275-80.
•Rabi DM, Khan N, Vallee M, Hladunewich MA, Tobe SW, Pilote L Reporting on sex-based analysis in clinical trials of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker efficacy. Can J Cardiol. 2008;24(6):491-6.
•Campbell NR, Khan NA, Hill MD, Tremblay G, Lebel M, Kaczorowski J, McAlister FA, Lewanczuk RZ, Tobe S; Canadian Hypertension Education Program. 2009 Canadian Hypertension Education Program recommendations: the scientific summary--an annual update. Can J Cardiol. 2009;25(5):271-7.
•Kalb K, Shalansky S, Legal M, Khan N, Ma I, Hunte G. Unintended Medication Discrepancies Associated with Reliance on Prescription Databases for Medication Reconciliation on Admission to a General Medical Ward. Canadian Journal of Hospital Pharmacy. 2009  62(4).
•Khan NA, Hemmelgarn B, Herman RJ, Bell CM, Mahon JL, Leiter LA, Rabkin SW, Hill MD, Padwal R, Touyz RM, Larochelle P, Feldman RD, Schiffrin EL, Campbell NR, Moe G, Prasad R, Arnold MO, Campbell TS, Milot A, Stone JA, Jones C, Ogilvie RI, Hamet P, Fodor G, Carruthers G, Burns KD, Ruzicka M, DeChamplain J, Pylypchuk G, Petrella R, Boulanger JM, Trudeau L, Hegele RA, Woo V, McFarlane P, Vallée M, Howlett J, Bacon SL, Lindsay P, Gilbert RE, Lewanczuk RZ, Tobe S; Canadian Hypertension Education Progr
•King KM, Khan NA, Quan H. Ethnic variation in acute myocardial infarction presentation and access to care. Am J Cardiol. 2009;103(10):1368-73. (also featured on OMNI television, CTV news Calgary).
•Padwal RS, Hemmelgarn BR, Khan NA, Grover S, McKay DW, Wilson T, Penner B, Burgess E, McAlister FA, Bolli P, Hill MD, Mahon J, Myers MG, Abbott C, Schiffrin EL, Honos G, Mann K, Tremblay G, Milot A, Cloutier L, Chockalingam A, Rabkin SW, Dawes M, Touyz RM, Bell C, Burns KD, Ruzicka M, Campbell NR, Vallée M, Prasad R, Lebel M, Tobe SW; Canadian Hypertension Education Program. The 2009 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 1--blood pressur
•Quan H, Khan N, Hemmelgarn B, Tu K, Chen G, Campbell N, Hill MD, Ghali W, McAlister F for the Canadian Hypertension Education Program Outcomes Research Task Force. Validation of a Case definition to Define Hypertension Using Administrative Data. Hypertension 2009; 54;1423-1428.
•Sedlak T, Pu A, Aymong E, Gao M, Khan N, Quan H and Humphries K. Gender differences in access to coronary angiography and revascularization following acute myocardial infarction: time trends from 1994 to 2002. Canadian Journal of Cardiology 2009 (accepted).
•Wenner JB, Norena M, Khan N, Palepu A, Ayas NT, Wong H, Dodek PM.  Reliability of intensive care unit admitting and comorbid diagnoses, race, elements of Acute Physiology and Chronic Health Evaluation II score, and predicted probability of mortality in an electronic intensive care unit database.J Crit Care. 2009 Jul 2. [epub ahead of print].
•Chen G, Khan N, Walker R, Quan H. Validating ICD coding algorithms for diabetes mellitus from administrative data. Diabetes Res Clin Pract. 2010 Apr 1. [Epub ahead of print].
•Chen G, Khan N, King K, Hemmelgarn B, Quan H. Home care service utilization and congestive heart failure outcomes: comparing Asian and white Canadian patients. BMC Cardiovasc Disord. 2010 Mar 4;10:12.
•Fowler RA, Noyahr LA, Thornton JD, Pinto R, Kahn JM, Adhikari NK, Dodek PM, Khan NA, Kalb T, Hill A, O'Brien JM, Evans D, Curtis JR; American Thoracic Society Disparities in Healthcare Group. An official american thoracic society systematic review: the association between health insurance status and access, care delivery, and outcomes for patients who are critically ill. Am J Respir Crit Care Med. 2010 May 1;181(9):1003-11.
•Hackam D, Khan NA, Hemmelgarn B, Herman RJ, Rabkin SW, McAlister FA, Bell CM, Touyz RM, Padwal R, Leiter LA, Mahon JL, Hill MD, Larochelle P, Feldman RD, Schiffrin EL, Campbell NR, Arnold MO, Moe G, Campbell TS, Milot A, Stone JA, Jones C, Ogilvie RI, Hamet P, Fodor G, Carruthers G, Burns KD, Ruzicka M, dechamplain J, Pylypchuk G, Petrella R, Boulanger JM, Trudeau L, Hegele RA, Woo V, McFarlane P, Vallée M, Howlett J, Katzmarzyk P, Tobe S, Lewanczuk RZ; Canadian Hypertension Education Program. The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2 Therapy. Can J Cardiol 2010 26(5): 249. 2010.
•Khan N, Campbell NRC, Frost SD, Gilbert K, Michota FA, Usmani A, Seal D, Ghali WA. Risk of Intraoperative Hypotension with Loop Diuretics: A Randomized Controlled Trial. Am J Med (accepted). 2010.
•Khan NA, Grubisic M, Hemmelgarn B, Humphries K, King K, Quan H. Outcomes after Acute Myocardial Infarction in South Asian, Chinese and White Patients. 2010 Circulation (accepted).
•Khan NA, Yun L, Humphries K, Robertson A, Silver FL, Kapral M. Antihypertensive Drug Use, Adherence and Outcomes After Stroke: Are There Sex Differences? Stroke 2010 (epub ahead of print).
•Liu R, So L,Mohan S, Khan N, King K, Quan H. Cardiovascular Risk Factors in Canadian Ethnic Populations: results from national surveys. 2010 Open Medicine. (accepted).
•Nijjar APK*, Wang H, Dasgupta K, Rabi DM, Quan H, Khan NA. Ethnic Differences in a Diabetic Population of South Asians and Whites Following Acute Myocardial Infarction. Cardiovasc Diabetol. 2010 Jan 22;9:4. (*denotes student where I am primary supervisor).
•Quan H, Khan N, Li B, Humphries KH, Evans D, Faris P, Galbraith PD, Graham M, Knudtson ML, Ghali WA. Invasive Cardiac Procedure Utilization and Mortality among South Asian and Chinese Canadians with Coronary Artery Disease. Canadian Journal of Cardiology (in press).
•Quinn R, Hemmelgarn B, Padwal R, Myers M, Cloutier L, Bolli P, Mackay D, Khan NA et al. The 2010 Canadian Hypertension Education Program Recommendations for the management of hypertension: Part 1 blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol 2010 26(5): 242.
•Walker R, Chen G, Campbell N, McAlister FA, Quan H, Tu K, Khan N, Hemmelgarn BR. Canadian Provincial Trends in Antihypertensive Drug Prescriptions between 1996 and 2006. Canadian Journal of Cardiology (accepted).
 

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